Water → HCID 66976471, compound

Participants

Reaction Steps

To a solution of tert-butyl (6R,7S)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (200 mg) and triethylamine (0.149 mL) in THF (4.0 mL) was added 4-nitrophenyl chloroformate (129 mg) under ice-cooling, and the mixture was stirred at room temperature for 5 hr. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (99 mg).

Provenance & Evidence