Water → HCID 66976868, compound

Participants

Reaction Steps

2-Chloroethanesulfonyl chloride (390 mg) was added dropwise to a solution of tert-butyl (6R,7S)-7-(aminomethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (600 mg) and triethylamine (0.67 mL) in THF (5 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (235 mg).

Provenance & Evidence