Water → HCID 66976367, compound

Participants

Reaction Steps

To a solution of tert-butyl (6SR,7RS)-6-(3,4-dichlorophenyl)-7-[(methylamino)methyl]-1,4-oxazepane-4-carboxylate (150 mg) in THF (5 mL) were successively added dropwise triethylamine (0.070 mL) and methanesulfonyl chloride (0.036 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (133 mg).

Provenance & Evidence