Hydrochloric Acid → HCID 86663877, compound

Participants

Reaction Steps

To a solution of tert-butyl (6R,7S)-7-[(acetylsulfanyl)methyl]-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (115 mg) in acetonitrile (1.1 mL) were added 1 N hydrochloric acid (0.13 mL) and N-chlorosuccinimide (141 mg), and the mixture was stirred at room temperature for 30 min. To the reaction solution was added brine, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (96 mg).

Provenance & Evidence