Water → HCID 66976187, compound

Participants

Reaction Steps

To a solution of tert-butyl (6R,7S)-7-[(chlorosulfonyl)methyl]-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (95 mg) in ethyl acetate (2.0 mL) were added triethylamine (0.06 mL) and isopropylamine (0.03 mL) under ice-cooling, and the mixture was stirred at room temperature overnight. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (33 mg).

Provenance & Evidence