Water → HCID 66976704, compound

Participants

Reaction Steps

To a solution of tert-butyl (6RS,7RS)-7-(2-aminoethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (140 mg) obtained in Example 484, step A in THF (3.0 ml) were added triethylamine (0.150 ml) and methoxyacetyl chloride (0.066 ml) under ice-cooling, and the mixture was stirred at room temperature for 2 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (157 mg).

Provenance & Evidence