Water → HCID 66976838, compound

Participants

Reaction Steps

To a solution of tert-butyl (6RS,7RS)-7-(2-aminoethyl)-6-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (135 mg) obtained in Example 484, step A in THF (3.0 mL) were added triethylamine (0.145 mL) and methanesulfonyl chloride (0.054 mL) under ice-cooling, and the mixture was stirred at room temperature for 2 hr. To the reaction solution was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate) to give the title compound (157 mg).

Provenance & Evidence