Isopropanol → HCID 66976042, compound

Participants

Reaction Steps

To a solution of chlorotris(triphenylphosphine)rhodium (I) (52 mg) and triphenylphosphine (620 mg) in tetrahydrofuran (5 mL) was added 2-propanol (0.18 mL), and tert-butyl (6S,7R)-6-(3,4-dichlorophenyl)-7-formyl-1,4-oxazepane-4-carboxylate (800 mg) was added. To the reaction mixture was added trimethylsilyldiazomethane (2 M diethyl ether solution, 2.1 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography to give the title compound (224 mg).

Provenance & Evidence