Sulfuryl chloride → HCID 57647079, compound

HRID 1022866Notes

Reaction equation

HRID 1022866 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[N:7][CH:6]=[CH:5]2.S(Cl)([Cl:15])(=O)=O>>[Cl:15][C:5]1[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[CH:8]=[N:7][CH:6]=1

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 218898476-Fluoroisoquinoline

Product 1

HCID 57647079HCID 57647079, compound

Procedure

A solution of 1.5 g 6-fluoro-isoquinoline (23) in 4.5 ml sulfuryl chloride was heated to 60° C. in a microwave reactor (CEM Discovery) for 8 h. After cooling to room temperature the mixture was poured on ice and extracted three times with CHCl3. After drying over Na2SO4 the solvent was distilled off and the crude product was purified by flash chromatography to yield 930 mg of compound 24.

Workup

  1. additionwas poured on ice
  2. extractionextracted three times with CHCl3
  3. dry with materialAfter drying over Na2SO4 the solvent
  4. distillationwas distilled off
  5. customthe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-e01c9d0887654078bfe9f35327949d6b
Source dataset
uspto-grants-2014_05
Patent number
US08722671B2

Reaction notes

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