4-[4-(4,4,4-Trifluoro-butyl)-isoquinolin-6-yloxy]-piperidine-1-carboxylic acid tert-butyl ester → 6-(Piperidin-4-yloxy)-4-(4,4,4-trifluoro-butyl)-isoquinoline

Participants

Reaction Conditions

Reaction Steps

42 mg of compound 89 were dissolved in 5M hydrochloric acid in isopropanol. The solution was stirred at room temperature for 2 hrs and another 2 hrs at 40° C., evaporated to dryness and taken up in water and lyophilized three times to give 32 mg of the desired product as the hydrochloride salt. LCMS Method #1, retention time 0.98 min, detected mass 338.16 [M+H]+

Provenance & Evidence