Methylamine → HCID 57646789, compound

Participants

Reaction Steps

154 mg (0.42 mmol) of 4-(1-Chloro-isoquinolin-6-yloxy)-piperidine-1-carbocyclic acid tert-butyl ester (162) were heated in 15 ml of an aqueous methylamine-solution (41%)) at 110° C. in a sealed tube. After 7 h the reaction mixture was evaporated and the residue was taken up in saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was separated, dried over magnesium sulfate and the solvent was removed i. vac. The residue was purified by silica gel chromatography (ethyl acetate/methanol 5:1). Yield: 45 mg. Rt=1.14 min (Method #4). Detected mass: 358.3 (M+H+).

Provenance & Evidence