HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(5-Nitro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Reactant | 6-Fluoro-5-nitroisoquinoline | HCID 20154047 | — |
| Reactant | 4-(Isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 57646754 | — |
| Product | 4-(5-Nitro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester | HCID 57646991 | — |
Reaction Steps
90 mg (0.47 mmol) 6-Fluoro-5-nitro-isoquinoline (152) were treated with 4-Hydroxy-piperidine-1-carboxylic acid tert-butyl ester following the method described for the preparation of compound 154.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722671B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c7b00443d84648d4857d6497c59fff96 |
| Source note | uspto-grants-2014_05 |