HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate → 1,4-Dioxa-7-azaspiro(4.4)nonane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate | HCID 15165037 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,4-Dioxa-7-azaspiro(4.4)nonane | HCID 15165039 | 100.1% |
Reaction Steps
To a solution of benzyl 1,4-dioxa-7-azaspiro[4.4]nonane-7-carboxylate (1.1 g) in methanol (30 mL) was added palladium(II) hydroxide (100 mg) at room temperature. The mixture was stirred for 2.5 hr under a hydrogen atmosphere (0.4 MPa). Insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (540 mg) as a dark orange liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722660B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-8e515c8ce78349318c9339c4e6a7e7ab |
| Source note | uspto-grants-2014_05 |