2,3-Dihydroxybutanedioic Acid → HCID 73013489, compound

In the same manner as in a document (Mi, Y.; Corey, E. J. Tetrahedron Lett. 2006, 47, 2515-2516), optical resolution by a diastereomer salt method was performed to synthesis the title compound. That is, to a solution of 1-azabicyclo[2.2.2]octane-2-carbonitrile (20.0 g) in methanol (100 mL) was slowly added a solution of (+)-tartaric acid (22.0 g) in methanol (100 mL) at 0° C. The reaction system was stirred for 90 min, and concentrated, and the obtained solid was crystallized 4 times from methanol. The precipitate was filtered off, and the filtrate was concentrated. To the residue was added water (150 mL), and sodium hydrogen carbonate was added to reach pH 8. The mixture was extracted with dichloromethane (200 mL×3), and the extract was washed with brine, dried, and concentrated. The obtained white solid (15.0 g) was dissolved in methanol (100 mL), and a solution of (−)-tartaric acid (16.5 g) in methanol (100 mL) was slowly added at 0° C. The reaction system was stirred for 90 min, and concentrated, and the obtained solid was crystallized 4 times from methanol to give (−)-tartrate of (2R)-1-azabicyclo[2.2.2]octane-2-carbonitrile (4.0 g, >90% ee). To the obtained solid was added water (50 mL), and sodium hydrogen carbonate was added to reach pH 8. The mixture was extracted with dichloromethane (100 mL×3), and the extract was washed with brine, dried, and concentrated. The obtained white solid (1.75 g) was dissolved in concentrated hydrochloric acid (50 mL), and the reaction mixture was heated under reflux overnight. After concentration, to the residue was slowly added a solution of sodium hydroxide (1.04 g) in water (10 mL) at 0° C. The mixture was concentrated, concentrated hydrochloric acid (5 mL) was added, and the mixture was concentrated again. The obtained white solid was extracted with methanol (10 mL). Insoluble material was filtered off, and the filtrate was concentrated to give the title compound (0.80 g).

1. concentrationconcentrated
2. customthe obtained solid was crystallized 4 times from methanol
3. filtrationThe precipitate was filtered off
4. concentrationthe filtrate was concentrated
5. additionTo the residue was added water (150 mL), and sodium hydrogen carbonate
6. additionwas added
7. extractionThe mixture was extracted with dichloromethane (200 mL×3)
8. washthe extract was washed with brine
9. customdried
10. concentrationconcentrated
11. dissolutionThe obtained white solid (15.0 g) was dissolved in methanol (100 mL)
12. additiona solution of (−)-tartaric acid (16.5 g) in methanol (100 mL) was slowly added at 0° C
13. stirringThe reaction system was stirred for 90 min
14. concentrationconcentrated
15. customthe obtained solid was crystallized 4 times from methanol

ORD record

ord-39d942664f0f4c339a463a895dbd9a0e

Source dataset

uspto-grants-2014_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08722660B2