Acetaldehyde → HCID 86676326, compound

Participants

Reaction Steps

A mixture of 1-[4-(4-acetyl-2-thiazolyl)-1-piperidinyl]-2-[5-methyl-3-trifluoromethyl)-1H-pyrazol-1-yl)ethanone (i.e. the product of Example 1, Step D) (4.5 g, 11.25 mmol) and hydroxylamine hydrochloride (0.945 g, 13.5 mmol) in methanol (60 mL) was heated at reflux for 6 h. The reaction mixture was concentrated under reduced pressure and partitioned between saturated sodium bicarbonate and dichloromethane. The organic phase was separated and the aqueous phase was extracted two additional times with dichloromethane. The organic phases were combined, washed with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated to provide 4.2 g of the title compound.

Provenance & Evidence