Diisopropylethylamine → HCID 86676330, compound

Participants

Reaction Steps

To a solution of 2,6-difluorobenzaldehyde (0.177 g, 1.25 mmol) in dichloromethane (5 mL) was added N-ethyl-N-(1-methylethyl)-2-propane amine (0.436 ml, 2.5 mmol) and 1,1,1-trifluoro-methanesulfonic acid, (1,1-dimethylethyl)dimethylsilyl ester (0.430 mL, 1.875 mmol). The reaction was stirred for 15 minutes and a solution of 1-[4-(4-acetyl-2-thiazolyl)-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)ethanone (i. e. the product of Example 1, Step D) (0.5 g, 1.25 mmol) dissolved in dichloromethane (2 mL) was added dropwise over 5 minutes. The resulting reaction was stirred for 6 hours and concentrated under reduced pressure. The residue was purified via silica gel chromatography (20% ethyl acetate: hexanes to 100% ethyl acetate eluant) to provide 0.62 g of the title compound.

Provenance & Evidence