HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,2,2-Trifluoro-1-[4-(thiazole-2-carbonyl)-piperazin-1-yl]-ethanone | HCID 59626129 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | Piperazin-1-yl(thiazol-2-yl)methanone | HCID 21641598 | 238.7% |
Reaction Steps
A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722658B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ffe586b4b5b14ee9bc1b14f9607b409e |
| Source note | uspto-grants-2014_05 |