HCID 71542038, compound → HCID 86680431, compound

HRID 1023191Notes

Reaction equation

HRID 1023191 reaction equation
ClC1C=C(NC2N(C)C(COC3[CH:18]=[C:19]4C(=CC=3)N[C:22](=[O:27])[CH:21]=[CH:20]4)=NN=2)C=CC=1Cl.[NH:29]1[C:37]2[C:32](=[CH:33][C:34]([CH2:38][CH2:39][C:40]3[N:41]([CH3:56])[C:42]([NH:45][C:46]4[CH:51]=[CH:50][C:49]([O:52][CH:53]([F:55])[F:54])=[CH:48][CH:47]=4)=[N:43][N:44]=3)=[CH:35][CH:36]=2)[CH:31]=[N:30]1>>[F:55][CH:53]([F:54])[O:52][C:49]1[CH:50]=[CH:51][C:46]([NH:45][C:42]2[N:41]([CH3:56])[C:40]([CH2:39][CH2:38][C:34]3[CH:33]=[C:32]4[C:37](=[CH:36][CH:35]=3)[N:29]([CH:22]3[CH2:21][CH2:20][CH2:19][CH2:18][O:27]3)[N:30]=[CH:31]4)=[N:44][N:43]=2)=[CH:47][CH:48]=1

Participants

3

Reactant 2

HCID 71542038HCID 71542038, compoundHCID 71542039HCID 71542039, compound

Product 1

HCID 86680431HCID 86680431, compound

Procedure

By a procedure analogous to the synthesis of 6-((5-(3,4-dichlorophenylamino)-4-methyl-4H-1,2,4-triazol-3-yl)methoxy)quinolin-2(1H)-one (Example 276), 5-(2-(1H-indazol-5-yl)ethyl)-N-(4-(difluoromethoxy)phenyl)-4-methyl-4H-1,2,4-triazol-3-amine (0.131 g, 16%) was synthesized as an off-white gum. LCMS: RT 1.858 min; LCMS (ES-API), m/z 469 (M+H).

Workup

  1. customwas synthesized as an off-white gum

Sources & evidence

ORD record
ord-ee4e7eefcf704280b50cbdf132094c0c
Source dataset
uspto-grants-2014_05
Patent number
US08722670B2

Reaction notes

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