HCID 66653522, compound → HCID 178496551, compound

HRID 1023232Notes

Reaction equation

HRID 1023232 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[CH3:28][O:29][C@@H:30]1[CH2:34][CH2:33][C@@H:32]([CH2:35][C:36](OC)=[O:37])[CH2:31]1>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:36](=[O:37])[CH2:35][C@@H:32]5[CH2:33][CH2:34][C@@H:30]([O:29][CH3:28])[CH2:31]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 66653522HCID 66653522, compoundHCID 178478587HCID 178478587, compound2×

Product 1

HCID 178496551HCID 178496551, compound

Procedure

The title compound, white solid (14 mg, 42%), MS (ISP) m/z=472.6 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (25.8 mg, 0.070 mmol) and methyl 2-((1R,3R)-3-methoxycyclopentyl)acetate

Sources & evidence

ORD record
ord-ed5c11acea934f7db2d839ab60eaef39
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

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