1-Methoxycyclohexane-1-carboxylic acid → HCID 178493932, compound

HRID 1023245Notes

Reaction equation

HRID 1023245 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[CH3:28][O:29][C:30]1([C:36](O)=[O:37])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:36]([C:30]5([O:29][CH3:28])[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]5)=[O:37])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 117688351-Methoxycyclohexane-1-carboxylic acidHCID 178478587HCID 178478587, compound2×

Product 1

HCID 178493932HCID 178493932, compound

Procedure

The title compound, white solid (17.4 mg, 40.8%), MS (ISP) m/z=472.1 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (30 mg, 81.5 mmol) and 1-Methoxycyclohexane-1-carboxylic acid.

Sources & evidence

ORD record
ord-4ab675ff916b4087b06b0871ba12ac52
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

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