4-(Morpholin-4-yl)benzoic acid → HCID 178523678, compound

HRID 1023249Notes

Reaction equation

HRID 1023249 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[O:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH:27][C:38](=[O:39])[C:37]5[CH:36]=[CH:35][C:34]([N:31]6[CH2:32][CH2:33][O:28][CH2:29][CH2:30]6)=[CH:42][CH:41]=5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 3452784-(Morpholin-4-yl)benzoic acidHCID 178478587HCID 178478587, compound2×

Product 1

HCID 178523678HCID 178523678, compound

Procedure

The title compound, white solid (16.3 mg, 38.4%), MS (ISP) m/z=421.4 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (30 mg, 81.5 mmol) and 4-morpholinobenzoic acid.

Sources & evidence

ORD record
ord-ddb78b71754c4082a57d10505feba20b
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

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