HCID 178478587, compound → HCID 178496549, compound

HRID 1023258Notes

Reaction equation

HRID 1023258 reaction equation
Cl.Cl.Cl.[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C@H:21]4[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1.[CH3:28][O:29][C@H:30]1[CH2:35][CH2:34][C@H:33]([CH2:36][C:37](O)=[O:38])[CH2:32][CH2:31]1>>[O:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH:21]4[CH2:26][CH2:25][CH:24]([NH:27][C:37](=[O:38])[CH2:36][C@H:33]5[CH2:34][CH2:35][C@H:30]([O:29][CH3:28])[CH2:31][CH2:32]5)[CH2:23][CH2:22]4)[CH2:15][CH2:14]3)[C:7]=2[O:6][CH2:5]1

Participants

3

Reactant 2

HCID 178478587HCID 178478587, compound2×HCID 178496559HCID 178496559, compound

Product 1

HCID 178496549HCID 178496549, compound

Procedure

The title compound, white solid (27.1 mg, 68.4%), MS (ISP) m/z=486.4 [(M+H)+], was prepared in accordance with the general method of example 1 from Trans-4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexylamine hydrochloride (Intermediate A) (30 mg, 81.5 mmol) and (trans-4-Methoxycyclohexyl)acetic acid (synthesized as described in W2009/013212 p. 73).

Sources & evidence

ORD record
ord-e942f549506046778ae1f1d081bc1b7f
Source dataset
uspto-grants-2014_05
Patent number
US08722683B2

Reaction notes

Loading…