Methyl iodide → HCID 178496757, compound

HRID 1023267Notes

Reaction equation

[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:23][CH2:22][C@H:21]([NH:24][C:25](=[O:31])[C@@H:26]([OH:30])[CH:27]([CH3:29])[CH3:28])[CH2:20][CH2:19]4)[CH2:12][CH2:11]3)[C:4]=2[O:3][CH2:2]1.[CH3:32]I>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:19][CH2:20][C@H:21]([NH:24][C:25](=[O:31])[C@@H:26]([O:30][CH3:32])[CH:27]([CH3:29])[CH3:28])[CH2:22][CH2:23]4)[CH2:12][CH2:11]3)[C:4]=2[O:3][CH2:2]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 178448393HCID 178448393, compound

Product 1

HCID 178496757HCID 178496757, compound

Procedure

The title compound, white solid (5.7 mg, 69%), MS (ISP) m/z=446.4 [(M+H)+], was prepared in accordance with the general method of example 62 from (S)-trans-N-{4-[2-(4-Benzo[1,3]dioxol-4-yl-piperazin-1-yl)-ethyl]-cyclohexyl}-2-hydroxy-3-methyl-butyramide (8 mg, 18.5 mmol) and methyl iodide.

Sources & evidence

ORD record: ord-cc5be1f03e3747bf84440638d2864fe1
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08722683B2

Reaction notes

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