HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → HCID 22452057, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | HCID 23159389 | HCID 23159389 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22452057 | HCID 22452057 | 94% |
Reaction Steps
Prepared from 4-[(3-Chloro-4-fluorophenyl)amino]-7-{3-[(tert-butyl-dimethylsilyl)oxy]propyloxy}-6-nitroquinazoline by splitting off the protective silyl group with tetrabutyl ammonium fluoride in tetrahydrofuran. Yield: 94% of theory; Rf value: 0.61 (silica gel, methylene chloride/methanol/concentrated aqueous ammonia solution=90:10:0.1); mass spectrum (ESI−): m/z=391, 393 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722694B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f831cbce005e43e5b8e851129fe2fdd9 |
| Source note | uspto-grants-2014_05 |