Ethylamine → 7-Chloro-5-(ethylamino)-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one

HRID 1023300Notes

Reaction equation

HRID 1023300 reaction equation
Cl[C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[CH:8]=[N:7][C:6]=2[CH:5]=[C:4]([Cl:14])[N:3]=1.[CH2:15]([NH2:17])[CH3:16]>C(Cl)Cl>[Cl:14][C:4]1[N:3]=[C:2]([NH:17][CH2:15][CH3:16])[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[CH:8]=[N:7][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 580929485,7-dichloro-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one

Product 1

HCID 866679787-Chloro-5-(ethylamino)-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5,7-dichloro-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one (1.5 g, 6.5 mmol) in DCM (10 mL) was added an aqueous ethylamine solution (70%, 8 mL, 6.368 g, 141.3 mmol). After stirring for 8 hours at room temperature, the reaction mixture was evaporated under reduced pressure to afford the title compound. ESI-MS m/z 239.1 (MH+).

Workup

  1. customthe reaction mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-3abb20b4fe3f44ef91ad34236c30629c
Source dataset
uspto-grants-2014_05
Patent number
US08722692B2

Reaction notes

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