Cesium carbonate → HCID 66959852, compound

Participants

Reaction Conditions

Reaction Steps

2-iodopyridine (7.51 μL, 0.071 mmol), Cs2CO3 (41.9 mg, 0.129 mmol), and a catalytic amount of Pd(OAc)2 and xant phos ligand were added to a solution of 5-amino-7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one (20.0 mg, 0.064 mmol) in anhydrous THF (0.5 mL). The reaction mixture was purged with N2 and heated at 85° C. overnight. The mixture was then cooled, quenched with H2O (5 mL) and extracted with ethyl acetate (3×2.5 mL). The combined organic layers were evaporated under vacuo and the residue was purified by preparatory LC/MS to provide the title compound; HPLC-MS calculated for C21H20N6O2 (M+H+) 389.2, found 389.2.

Provenance & Evidence