5-Formyl-2-thiopheneboronic acid → 5-Hydroxymethylthiophene-2-boronic acid

Participants

Reaction Steps

To a solution of 5-formylthiophen-2-ylboronic acid (15.6 mg, 0.1 mmol) in MeOH (0.5 mL) was added excess amount of NaBH4. The mixture was stirred at room temperature for 2 hours and evaporated under reduced pressure to afford crude 5-(hydroxymethyl)thiophen-2-ylboronic acid, which was used in step E without further purification.

Provenance & Evidence