Cesium carbonate → HCID 67326575, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 4-{4-[2-(4-iodophenoxy)ethyl]benzyl}piperazine-1-carboxylate (209 mg), potassium cyclopropyltrifluoroborate (86 mg), Pd(OAc)2 (6 mg), di(1-adamantyl)-n-butyl-phosphine (13 mg), Cs2CO3 (391 mg), and toluene/water (10:1) (3.3 mL) were mixed in a 5 mL process vial. The vial was sealed, and the reaction mixture was heated with microwaves to 130° C. for 1 hour. After filtration through a Celite pad, the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=1/0 to 0/1) to give tert-butyl 4-{4-[2-(4-cyclopropylphenoxy)ethyl]benzyl}piperazine-1-carboxylate as a pale yellow solid (40 mg).

Provenance & Evidence