Thioglycolic Acid → HCID 67327651, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[4-(2-{(4-methoxyphenyl)[(2-nitrophenyl)sulfonyl]-amino}ethyl)benzyl]piperazine-1-carboxylate in DMF (35 mL) was added mercaptoacetic acid (1.35 mL) and LiOH (1.63 g) at room temperature, then the reaction mixture was stirred over night. The reaction mixture was added mercaptoacetic acid (1.35 mL) and LiOH (1.63 g), and stirred for 5 hours. The reaction mixture was diluted with H2O, and extracted with AcOEt. The organic layer was washed with water and saturated aqueous NaCl, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=1/1 to 1/2) to afford tert-butyl 4-(4-{2-[(4-methoxyphenyl)amino]ethyl}benzyl)piperazine-1-carboxylate as a pale yellow amorphous (5.96 g).

Provenance & Evidence