Piperidine → HCID 86673384, compound

Participants

Reaction Steps

To a solution of 9H-fluoren-9-ylmethyl 4-(4-{(E)-3-[(5-bromopyridin-2-yl)oxy]-prop-1-en-1-yl}benzyl)piperazine-1-carboxylate (0.604 g) in CH2Cl2 (10 mL) was added piperidine (0.196 mL). After stirring at room temperature for 1 hour, to the reaction mixture was added piperidine (0.784 mL) and stirred at room temperature for 4 hours. Then to the reaction mixture was added saturated aqueous NH4Cl and CH2Cl2. The organic layer was washed with saturated aqueous NH4Cl and saturated aqueous NaCl, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was washed with Et2O to afford 1-(4-{(E)-3-[(5-bromopyridin-2-yl)oxy]prop-1-en-1-yl}benzyl)piperazine as a white powder (0.282 g).

Provenance & Evidence