Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 86673390, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(trimethylsilyl)ethyl (E)-3-{4-[(5-{[tert-butyl(dimethyl)silyl]-oxy}pyridin-2-yl)oxy]-3-chloro-5-methylphenyl}but-2-enoate (0.630 g) in EtOH (12 mL) was added PPTS (0.296 g) at room temperature, then the reaction mixture was stirred for 4 days. The reaction mixture was warmed to 60° C., and stirred over night. The reaction mixture was concentrated under reduced pressure. The residue was diluted with pH 7 phosphate buffer, and extracted with AcOEt. The organic layer was washed with water and saturated aqueous NaCl, dried over anhydrous Na2SO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane/AcOEt=8/1 to 2/1) to afford 2-(trimethylsilyl)ethyl (E)-3-{3-chloro-4-[(5-hydroxypyridin-2-yl)oxy]-5-methylphenyl}but-2-enoate as a colorless oil (0.490 g).

Provenance & Evidence