Hydrochloric Acid → HCID 53308759, compound

Participants

Reaction Steps

To a solution of (E)-3-[3-chloro-5-methyl-4-({5-[(4-methylbenzyl)oxy]pyridin-2-yl}oxy)phenyl]-1-(4-{4-[2-(4-chlorophenoxy)ethyl]benzyl}piperazin-1-yl)prop-2-en-1-one (3.410 g) in EtOH (50 mL) was added 6 M HCl (0.86 mL) at 50° C. The mixture was stirred at room temperature for 16 hours. The resulting precipitate was collected, and crystallized from EtOH (300 mL) and water (100 mL) to give (E)-3-[3-chloro-5-methyl-4-({5-[(4-methylbenzyl)oxy]pyridin-2-yl}oxy)phenyl]-1-(4-{4-[2-(4-chlorophenoxy)ethyl]benzyl}piperazin-1-yl)prop-2-en-1-one hydrochloride (3.060 g) as a colorless powder.

Provenance & Evidence