Ammonia → 6-Bromo-2,3-dihydro-1H-isoindol-1-one

HRID 1023395ノート

反応式

HRID 1023395 の反応式
[NH3:1].C[O:3][C:4](=O)[C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:6]=1[CH2:12]Br>CO>[Br:11][C:9]1[CH:10]=[C:5]2[C:6]([CH2:12][NH:1][C:4]2=[O:3])=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 12929136Methyl 5-bromo-2-(bromomethyl)benzoate

生成物 1

HCID 222209196-Bromo-2,3-dihydro-1H-isoindol-1-one収率 67%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

To a saturated solution of NH3 in CH3OH (50 mL) was added 5-bromo-2-bromomethyl-benzoic acid methyl ester (4.8 g, 16 mmol). The reaction mixture was stirred in a sealed tube at 40° C. overnight. The mixture was cooled to room temperature and the resultant white solid was collected to afford 6-bromoisoindolin-1-one (2.2 g, 67%). 1H NMR (400 MHz, DMSO) δ 8.71 (s, 1H), 7.75 (d, 2H), 7.53 (s, 1H), 4.32 (s, 2H).

後処理

  1. temperatureThe mixture was cooled to room temperature
  2. customthe resultant white solid was collected

出典と根拠

ORDレコード
ord-72743ebf0b044218a4f6b24621b86ae2
出典データセット
uspto-grants-2014_05
特許番号
US08722704B2

反応ノート

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