HRID1023409

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13843024

1-Phenylpiperazin-2-one

C10H12N2O

结构：COc1ccc(C2(C(=O)Nc3cc4ccccc4c(N4CCN(c5ccccc5)C(=O)C4)n3)CC2)cc1

HCID57733023

未命名化合物

结构：COc1ccc(C2(C(=O)Nc3cc4ccccc4c(Br)n3)CC2)cc1

HCID57733030

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C2(C(=O)Nc3cc4ccccc4c(N4CCN(c5ccccc5)C(=O)C4)n3)CC2)cc1

HCID86701221

未命名化合物

PROCEDURE

实验过程

1-(4-methoxyphenyl)-N-(1-(3-oxo-4-phenylpiperazin-1-yl)isoquinolin-3-yl)cyclopropanecarboxamide was made by the procedure shown above starting from N-(1-bromoisoquinolin-3-yl)-1-(4-methoxyphenyl)cyclopropanecarboxamide and 1-phenylpiperazin-2-one.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0067bfdcbb704e6196c4b4d2ec44e068
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08722704B2
来源说明: uspto-grants-2014_05

反应 SMILES

CO[C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([NH:14][C:15]3[N:16]=[C:17]([N:25]4[CH2:30][CH2:29][N:28]([C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)[C:27](=[O:37])[CH2:26]4)[C:18]4[C:23]([CH:24]=3)=[CH:22][CH:21]=[CH:20][CH:19]=4)=[O:13])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Br[C:39]1C2C(=CC=CC=2)C=C(NC(C2(C3C=CC(OC)=CC=3)CC2)=O)N=1.C1(N2CCNCC2=O)C=CC=CC=1>>[CH3:39][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:12]([NH:14][C:15]3[N:16]=[C:17]([N:25]4[CH2:30][CH2:29][N:28]([C:31]5[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=5)[C:27](=[O:37])[CH2:26]4)[C:18]4[C:23]([CH:24]=3)=[CH:22][CH:21]=[CH:20][CH:19]=4)=[O:13])[CH2:10][CH2:11]2)=[CH:5][CH:4]=1