Trifluoroacetic acid → HCID 86673604, compound

Participants

Reaction Conditions

Reaction Steps

(4-Fluoro-phenyl)-hydrazine hydrochloride (95 mg, 0.57 mmol) is dissolved in isopropanol (3.0 mL) and triethylamine (0.08 mL, 0.57 mmol) is added. After the mixture is stirred for 5 min, trifluoroacetic acid (0.09 mL, 1.19 mmol) is added and the mixture is again stirred for 5 min Then 1-(2-Chloro-pyridin-4-yl)-4,4,4-trifluoro-butane-1,3-dione (130 mg, 0.52 mmol) is added and the reaction mixture is heated at 85° C. for 40 hrs and stirred at room temperature for another 48 hrs. Water (20 mL) is added and 1.0 M NaOH solution is used to adjust the pH to about 6. The reaction mixture is then extracted with EtOAc (3×20 ml) and the organic layers are combined and concentrated to give the crude product, which is used without purification.

Provenance & Evidence