Ammonium Hydroxide → HCID 69084435, compound

Participants

Reaction Conditions

Reaction Steps

A 2 mL microwave reaction tube is charged with the mixture of E and Z 2-bromo-4-(2-o-tolyl-vinyl)-pyridine (510 mg, 1.9 mmol), Copper (I) oxide (53 mg, 0.37 mmol), Ammonium Hydroxide (28%, 0.5 mL) and 1-4-dioxane (0.5 mL). The reaction mixture is heated at 150° C. for 30 min in a microwave reactor. Then water (5 mL) is added and the mixture is extracted with EtOAc (3×20 mL). The combined organic layers are washed with brine, dried over anhydrous sodium sulfate and concentrated. The crude is purified by silica flash column chromatography eluting with EtOAc in Heptane (gradient from 0% to 100%) to give the desired mixture of products (210 mg).

Provenance & Evidence