Benzoyl isocyanate → HCID 69082673, compound

HRID 1023423Notes

Reaction equation

HRID 1023423 reaction equation
[C:1]1([CH3:16])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[CH:10]=1.[C:17]([N:25]=[C:26]=[O:27])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)Cl>[C:17]([NH:25][C:26]([NH:15][C:11]1[CH:10]=[C:9]([CH2:8][CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:16])[CH:14]=[CH:13][N:12]=1)=[O:27])(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 78210Benzoyl isocyanateHCID 57040977HCID 57040977, compound

Product 1

HCID 69082673HCID 69082673, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
65 °C

Procedure

4-(2-o-Tolyl-ethyl)-pyridin-2-ylamine (100 mg, 0.47 mmol) is dissolved in methylene chloride (3 mL). Then benzoyl isocynate (100 mg, 0.71 mmol) is added. The resulting mixture is sealed and heated at 65° C. for 1 hour. The solvent is then removed to give 225 mg of crude which is used in the next step without purification.

Workup

  1. customThe resulting mixture is sealed
  2. customThe solvent is then removed
  3. customto give 225 mg of crude which
  4. customis used in the next step without purification

Sources & evidence

ORD record
ord-146be9f9b6844c368286095c725dfe49
Source dataset
uspto-grants-2014_05
Patent number
US08722709B2

Reaction notes

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