HCID 69083506, compound → HCID 69082589, compound

Participants

Reaction Steps

To the solution of the mixture of [4-((E)-2-p-Tolyl-vinyl)-pyridin-2-yl]-urea and [4-(2-hydroxy-2-p-tolyl-ethyl)-pyridin-2-yl]-urea (36 mg) in ethanol (3 mL) is added 5% palladium on carbon (5 mg). The mixture is purged and back filled with hydrogen three times using a hydrogen balloon. Then the reaction is stirred for 3 hours under the hydrogen atmosphere. The palladium on carbon is filtered and the filtrate is purified by Gilson preparative HPLC to give 12 mg of [4-(2-p-tolyl-ethyl)-pyridin-2-yl]-urea and 3 mg of [4-(2-hydroxy-2-p-tolyl-ethyl)-pyridin-2-yl]-urea.

Provenance & Evidence