[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea → [4-(2-Phenyl-2-o-tolyl-ethyl)-pyridin-2-yl]-urea

Participants

Reaction Steps

[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea (140 mg, 0.43 mmol) is dissolved in methanol (2 mL) and DCM (2 mL). Then 5% palladium on carbon (90 mg, 0.043 mmol) is added. The reaction is stirred for 16 hours under the hydrogen atmosphere. The palladium on carbon is filtered and the filtrate is concentrated to give the crude product. Purification by Gilson preparative HPLC affords 20 mg of the titled product.

Provenance & Evidence