Water → HCID 178514065, compound

Participants

Reaction Steps

To the solution of {4-[3-(2,4-Dimethoxy-benzyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridin-2-yl}-urea (Example 51, 15 mg, 0.034 mmol) in DCM (1.0 mL) is added trifluoroacetic acid (0.1 mL). The reaction mixture is stirred for 6.5 days at room temperature before saturated NaHCO3 aqueous solution (2 mL) is added along with water (10 ml). The mixture is extracted with EtOAc (3×20 mL) and the organic layers are combined, dried and concentrated to give the crude product. Purification by silica flash column chromatography using 10% MeOH in DCM affords 9.7 mg of the titled product.

Provenance & Evidence