Trifluoroacetic acid → HCID 178505559, compound

Participants

Reaction Steps

2-Bromo-4-[3-(2,4-dimethoxy-benzyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine (720 mg, 1.54 mmol) is dissolved in DCM (12 mL) and trifluoroacetic acid (3.0 mL) is added at room temperature. The mixture is stirred for 60 hrs before saturated NaHCO3 aqueous solution is used to adjust the pH to about 7.5. Then the mixture is extracted with EtOAc (3×30 mL). The organic layers are combined and concentrated to give the crude product. The crude is purified by silica flash column chromatography using MeOH in DCM (gradient from 0% to 10%) to give 316 mg of desired product.

Provenance & Evidence