Water → HCID 69083608, compound

Participants

Reaction Conditions

Reaction Steps

2-Bromo-4-[4-(4-fluoro-phenyl)-oxazol-5-yl]-pyridine (700 mg, 2.19 mmol), 28% aqueous ammonium hydroxide solution (14 mL) and Copper (I) oxide (314 mg, 2.19 mmol) are mixed in 1,4-dioxane (14 mL) in a microwave reaction tube. The tube is sealed and heated at 150° C. for 25 min in a microwave reactor. Then water (80 mL) is added and the mixture is extracted with EtOAc (3×50 ml). The organic layers are combined and concentrated to give the crude product. Purification by silica flash column chromatography using MeOH in DCM (gradient from 0% to 10%) affords 320 mg of desired product.

Provenance & Evidence