4-[2-(4-Fluoro-phenyl)-cyclohex-1-enyl]-pyridin-2-ylamine → 4-[cis-2-(4-Fluoro-phenyl)-cyclohexyl]-pyridin-2-ylamine

Participants

Reaction Steps

A solution of 4-[2-(4-Fluoro-phenyl)-cyclohex-1-enyl]-pyridin-2-ylamine (220 mg, 0.82 mmol, synthesis described in example 56) in methanol (10 mL) is passed through H-Cube® Continuous-flow Hydrogenation Reactor at 60° C. and under 60 psi hydrogen pressure. The 10% Pd/C cartridge is used and the reaction is run for 48 hours. The solvent is removed to give 120 mg of the desired product.

Provenance & Evidence