1-Aminocyclopropane-1-carboxylic acid → 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

HRID 1023574Notes

Reaction equation

HRID 1023574 reaction equation
[CH3:1][C:2]([O:5][C:6]([NH:8][C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]C1)=[O:7])([CH3:4])[CH3:3].NC1(C(O)=O)CCC1.NC1(C(O)=O)CC1>>[CH3:4][C:2]([O:5][C:6]([NH:8][C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]1)=[O:7])([CH3:1])[CH3:3]

Participants

4

Reactant 3

HCID 5351-Aminocyclopropane-1-carboxylic acidHCID 896431-Aminocyclobutanecarboxylic acidHCID 1512646Cyclobutanecarboxylic acid, 1-(((1,1-dimethylethoxy)carbonyl)amino)-

Product 1

HCID 6883961-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

Procedure

The title compound (998 mg) was made in a similar fashion to the preparation of Intermediate 100 replacing 1-aminocyclobutanecarboxylic acid with 1-aminocyclopropanecarboxylic acid (550 mg, 5.44 mmol).

Sources & evidence

ORD record
ord-5759e709858f48a8875c0226757a50d5
Source dataset
uspto-grants-2014_05
Patent number
US08722695B2

Reaction notes

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