HCID 68322458, compound → HCID 67235871, compound

HRID 1023575Notes

Reaction equation

HRID 1023575 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[N:14]=[CH:13][C:12]([NH:15][C:16]([C:18]3([NH:22]C(=O)OC(C)(C)C)[CH2:21][CH2:20]C3)=[O:17])=[CH:11][CH:10]=2)=[CH:4][C:3]=1[O:30][CH3:31].CC1C=CC(OC2N=CC(NC(C3(NC(=O)OC(C)(C)C)CC3)=O)=CC=2)=CC=1OC>>[NH2:22][C:18]1([C:16]([NH:15][C:12]2[CH:13]=[N:14][C:9]([O:8][C:5]3[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([O:30][CH3:31])[CH:4]=3)=[CH:10][CH:11]=2)=[O:17])[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 68322458HCID 68322458, compound2×HCID 68322620HCID 68322620, compound

Product 1

HCID 67235871HCID 67235871, compound

Procedure

The title compound (58 mg) was made in a similar fashion to the preparation of Intermediate 102 replacing 1,1-dimethylethyl (1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}cyclobutyl)carbamate with 1,1-dimethylethyl (1-{[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]carbonyl}cyclopropyl)carbamate (Intermediate 104, 80 mg)

Sources & evidence

ORD record
ord-74846d775d334b25b725468b37cc4b90
Source dataset
uspto-grants-2014_05
Patent number
US08722695B2

Reaction notes

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