HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 66546473, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | HCID 77136682 | HCID 77136682 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | HCID 66546473 | HCID 66546473 | 28% |
Reaction Steps
rac-(5R,7R,8R)-8-hydroxy-7-(2,2,2-trifluoroethoxy)-2-(4-(trifluoromethoxy)phenyl)-2-azaspiro[4.5]decan-1-one (25 mg, obtained in example 6) was subjected to resolution by preparative HPLC (Chiralpack AD, 30% isopropanol in heptane) to provide (5R,7R,8R)-8-hydroxy-7-(2,2,2-trifluoro-ethoxy)-2-(4-trifluoromethoxy-phenyl)-2-aza-spiro[4.5]decan-1-one (7 mg), MS (ESI): 428.2 (MH+),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722721B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-0dd660b9e11d4eaaaaf3920b3cd22cc4 |
| Source note | uspto-grants-2014_05 |