HCID 86671111, compound → HCID 86671110, compound

Participants

Reaction Steps

(5R,7R,8R) and (5S,7S,8S)-2-(4-((R)-1-(benzyloxy)-2,2,2-trifluoroethyl)phenyl)-8-hydroxy-7-(2,2,2-trifluoroethoxy)-2-azaspiro[4.5]decan-1-one (174 mg, from Example 17) was dissolved in methanol (12 mL). Palladium on activated charcoal (10% Pd, 52 mg) was added and the mixture was purged with hydrogen (4 times). The reaction mixture was stirred under hydrogen at RT for 3 hours. The catalyst was removed by filtration over a filter aid (dicalite, Acros Organics), washed with additional ethyl acetate and the filtrate was evaporated. The crude material was purified by flash chromatography (gradient of ethyl acetate in heptane) to provide the title compound as a colorless foam (144 mg). MS (ESI): 442.3 (MH+).

Provenance & Evidence