Potassium Hydroxide → Potassium 4-[{[(4-fluorophenyl)methyl]imino}(hydroxy)methyl]-1-methyl-2-{2-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]propan-2-yl}-6-oxo-1,6-dihydropyrimidin-5-olate

Participants

Reaction Steps

A vial (20 ml) was charged with Raltegravir free hydroxy (500 mg) and cyclohexane (2.5 ml) at room temperature. A solution of 30% aqueous KOH (0.162 ml) was added. An additional amount of cyclohexane (5 ml) was added. The mixture was stirred for 25 h at room temperature. A gel solid precipitated and was removed Form the mixture using a spatula and was then filtered under reduced pressure to produce wet Raltegravir potassium crystalline Form V. The product was dried overnight in a vacuum oven at 40° C. to provide raltegravir potassium crystalline Form V.

Provenance & Evidence