HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Raltegravir
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium 4-[{[(4-fluorophenyl)methyl]imino}(hydroxy)methyl]-1-methyl-2-{2-[(5-methyl-1,3,4-oxadiazole-2-carbonyl)amino]propan-2-yl}-6-oxo-1,6-dihydropyrimidin-5-olate | HCID 23668479 | — |
| Solvent | Water | HCID 962 | — |
| Product | Raltegravir | HCID 54671008 | 99% |
Reaction Steps
A solution of Raltegravir potassium (˜3.4 g) in water was acidified with 2N HCl until pH 2 was obtained. The acidified solution was extracted with mixture of methyl tert-butyl ether (MTBE)/isopropyl alcohol (IPA) (400 ml/100 ml). The organic extract was evaporated to dryness. Raltegravir free hydroxy (3.1 g) was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722722B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-e62f058f5185464aa178bf975f4c4aa7 |
| Source note | uspto-grants-2014_05 |