HCID 67045214, compound → HCID 57639795, compound

HRID 1023689Notes

Reaction equation

HRID 1023689 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[C:11](=[O:13])[N:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:9]2)([O-])=O>C1C=CC=CC=1.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[C:11](=[O:13])[N:10]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH2:9]2

Participants

4

Reactant 1

HCID 67045214HCID 67045214, compound

Product 1

HCID 57639795HCID 57639795, compoundYield 96.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 241BenzeneSolvent

Procedure

7-Nitro-2-phenyl-2,3-dihydro-isoindol-1-one (0.19 g) obtained in Example 25 was catalytically reduced in the presence of 10% palladium/carbon (0.18 mg) in benzene (250 ml). The reaction solution was filtered, and concentrated under reduced pressure. The resulting residue was purified by recrystallization (ethanol) to obtain 7-amino-2-phenyl-2,3-dihydro-isoindol-1-one as a pale yellow powdery substance (0.16 g, yield: 96.4%).

Workup

  1. filtrationThe reaction solution was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe resulting residue was purified by recrystallization (ethanol)

Sources & evidence

ORD record
ord-3f4d6b94c24a4f73b17c7b11b237211e
Source dataset
uspto-grants-2014_05
Patent number
US08722723B2

Reaction notes

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